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[+ object], 1 : to make (someone) impatient, angry, or annoyed, It's his arrogance that really irritates me. The other passengers were irritated by the child's rudeness. 2 : to make (part of your body) sore or painful, Harsh soaps can irritate the skin. — irritated adjective [more irritated; most irritated], I've never seen him looking so irritated. an area of skin that is very irritated and sore